1. INTRODUCTION
2. SEQUENCE DATABASES
   • An historical overview.
   • The main databases. Structure and access.
   • The derived databases.
   • Browsing and querying.
3. SEQUENCE ALIGNMENT AND SEQUENCE SIMILARITY
   • Sequence alignment.
   • Sequence similarity.
   • Optimal global alignment. Dynamic Programming.
   • Substitution matrices.
   • Gap Penalties.
   • Local Alignments.
   • Multiple Alignments.
4. DATABASE SIMILARITY SEARCHES
   • FASTA
   • BLAST
   • Searching Databases. Practical aspects.
5. PATTERN RECOGNITION IN BIOLOGICAL SEQUENCES
   • Sequence Patterns.
   • Position Weigth Matrices
   • Identification of functional domains in sequences.
   • Sensitive Similariry Searches.
6. IN SILICO GENE IDENTIFICATION
   • Coding Statistics.
   • Sequence patterns involved in gene specification.
   • Integration of signals and statisticis for gene prediction.
   • Accuracy of gene predictions.
   • Gene Identification in Genome Projects.
   • Prediction of Promoter Regions.
7. Books
8. Documents on the Net
9. About this Document

BOOKS (rather old)

• Sequence Analysis in Molecular Biology.
  G.v Heijne. Academic Press (1987)
  
  
• Nucleic Acid and protein sequence analysis.
  M.J.Bishop and C.J.Rawlings, eds. IRL Press (1987)
  
  
• Sequence Analysis Primer.
  M.Gribskov and J.Devereux, eds. W.H.Freeman and Company (1992)
  
  
• Guide to Human Genome Computing.
  M.J.Bishop, ed. Acadmic Press (1994)
  
  
• Automated DNA Sequencing and Analysis.
  M.D.Adams, C. Fields, J.C.Venter, eds. Academic Press (1994)
  
  
• Introduction to Computational Biology.
  M.S. Waterman. Chapman& Hall (1995)
  
  
• Internet for the Molecular Biologist.
  S.R.Swindell, R.R.Miller and G.Myers, eds. Horizon Scientific Press (1996)

DOCUMENTS on the NET

• Computational Analysis of DNA and Protein Sequences by Baxevanis, Boguski and Oullete (NCBI)
• Algorithms for Molecular Biology by Naor and Shamir (Tel Aviv Univeristy)
• Algorithms in Molecular Biology by Karp, Ruzzo and Tompa (University of Washington)
• BioComputing course on the Internet by Georg Fuellen (University of Bielefeld)
• Guide to Sequence Search by Keith Robison (Harvard University)
• Georg Fuellen's list of links to Bioinformatics courses (University of Bielefeld)

ABOUT this DOCUMENT

You can send suggestions to Roderic Guigó from here.