| |
GeneRIF: Gene References into Function: |
| |
11702849 |
|
| |
11787735 |
- data reveal the presence of leptin in term human milk
|
| |
12047393 |
- rose in glucose metabolism in type 2 diabetes (review)
|
| |
12084725 |
- induction of leptin gene expression by hypoxia and HIF1
|
| |
12215445 |
- promoter is transactivated by hypoxia-inducible factor 1
|
| |
12189588 |
- a key role in metabolic syndrome, especially in the obesity
|
| |
12230820 |
- serum leptin levels of the patients with premature ejaculation
|
| |
12054648 |
- mediates a proliferative response in human MCF7 breast cancer cells
|
| |
12003376 |
- Higher serum leptin level in women than in men with type 1 diabetes.
|
| |
11886494 |
- Human follicular papilla cells carry out nonadipose tissue production
|
| |
12140788 |
- modifications in circulating levels across the eating disorder spectrum
|
| |
3952 |
- is there a correlation between serum leptin levels and binge eating in women?
|
| |
12880122 |
- leptin is not only an adipostatic hormone but also a stress-related hormone.
|
| |
12073010 |
- Genetic diversity and evolution of the human leptin locus tetranucleotide repeat
|
| |
12050272 |
- Leptin gene polymorphism is associated with hypertension independent of obesity.
|
| |
12133430 |
- The changes in plasma leptin, insulin and proinsulin levels in obese adolescents
|
| |
12324651 |
- role of leptin in energy balance and reproduction; effects of exercise on leptin [review]
|
| |
12724016 |
- serum leptin concentration reflects fat mass and postmenopausal bone mass in human subjects
|
| |
11920898 |
- Fetal Down syndrome or Edwards syndrome does not seem to alter maternal leptin concentration
|
| |
12788897 |
- Serum adiponectin and soluble leptin receptor were out-of-phase with leptin diurnal rhythms.
|
| |
12402972 |
- Body fat distribution does not serve as a predictor of leptin levels in postmenopausal women.
|
| |
11979399 |
- microsatellite polymorphism in exon 3 of POMC is associated with elevated serum leptin levels
|
| |
12665505 |
- Leptin induces apoptosis via ERK/cPLA2/cytochrome c pathway in human bone marrow stromal cells
|
| |
12359239 |
- enhances the effect of transforming growth factor beta in increasing type I collagen formation
|
| |
12200109 |
- leptin has a role in advanced lung cancer, but is not causative in cancer cachexia or anorexia
|
| |
12396559 |
- term pregnancy human umbilical cord and fetal membranes co-express leptin and its receptor genes
|
| |
11822578 |
- leptin level was significantly lower in the CDGP (constitutional delay of growth and puberty)group
|
| |
12199340 |
- Serum leptin and leptin binding activity in children and adolescents with hypothalamic dysfunction.
|
| |
12637980 |
- Positive independent correlation of the CAG repeat number with body fat content, leptin and insulin.
|
| |
12519883 |
- people with spinal cord injury have a significantly higher plasma leptin level than able-bodied people
|
| |
12105281 |
- a quantitative trait locus on chromosome 22 may influence the level of leptin adjusted for testosterone
|
| |
12473840 |
- Adiponectin and leptin levels in HIV-infected subjects with insulin resistance and body fat redistribution
|
| |
12086939 |
- serum level affects regulation of circulating soluble leptin reeptor levels, depending on gender, adiposity
|
| |
12153747 |
- AHSG, TNF-alpha and leptin may contribute to insulin resistance during normal pregnancy and gestational diabetes
|
| |
12865594 |
- data demonstrate that placental insufficiency is associated with a dramatic increase in placental leptin production
|
| |
12634434 |
- high leptin levels predict weight gain, suggesting that leptin resistance plays a role in the development of obesity
|
| |
12482897 |
- Leptin, via PI 3-kinase-driven activation of BK channels, elicits novel mechanism for controlling neuronal excitability.
|
| |
12189581 |
- polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin
|
| |
12829648 |
- dose-dependent effects of insulin on plasma ghrelin and leptin concentrations in nondiabetic and type 2 diabetic patients
|
| |
11934840 |
- leptin upregulates ET-1 production in HUVECs via a mechanism potentially involving jun binding members of the bZIP family
|
| |
12805252 |
- results indicate that postprandial leptin response is lower after a carbohydrate meal in obese women than in lean controls
|
| |
12010881 |
- Novel human and mouse genes encoding an acid phosphatase family member and its downregulation in W/Wv mouse jejunum [ACPL1]
|
| |
12659876 |
- evidence that insulin and hypoxia act as agonists on the human leptin transcription but on two different regulatory elements
|
| |
12512839 |
- leptin levels of bone marrow-derived plasma in childhood acute lymphoblastic leukemia were found to be significantly lowered
|
| |
12687277 |
- serum leptin and prolactin levels does not seem to be related with angiogenic activity and metastasis in breast cancer patients.
|
| |
12105280 |
- during weight loss leptin levels decreased, whereas soluble leptin receptor levels and the receptor bound fraction of leptin increased
|
| |
12153737 |
- inverse correlation found between adiponectin and leptin with serum leptin concentrations increased in women with high body mass index
|
| |
12556356 |
- Plasma leptin decreased with fasting in both spinal cord injury and controls, with leptin decrease being delayed in spinal cord injury.
|
| |
14561193 |
- effects of leptin in the immune system can be found in both the antigen-specific immunity and in the inflammatory effector system--REVIEW
|
| |
12062855 |
- polymorphism found to be associated with exercise-mediated improvement in glucose tolerance and leptin resistance in healthy Japanese men
|
| |
12445819 |
- Data show that stimulation of leptin internalisation by arachidonic acid in placental trophoblasts may be mediated via prostaglandin E(2).
|
| |
12393845 |
- Leptin deficiency was associated with reduced numbers of circulating CD4(+) T cells and impaired T cell proliferation and cytokine release.
|
| |
12053815 |
- The role of leptin in satiety and sex maturation, regulation of leptin secretion, and its possible therapeutic use in obesity are reviewed.
|
| |
12713059 |
- Leptin plasma levels were significantly higher in HIV-infected men with lipodystrophy as compared to HIV-infected controls (5.2 vs 3.0 ng/ml
|
| |
12748507 |
- Strong associations between cord leptin levels and other measures of fetal growth in both groups and with glycemic control in diabetic group.
|
| |
12707489 |
- Sleep disturbances in anorectics may be mediated through changes in the levels of the GH-IGF-1 axis hormones, as well as the levels of leptin.
|
| |
12690084 |
- study shows that serum leptin levels are directly related to 24-hour blood pressure levels in normotensive women with android fat distribution
|
| |
12658369 |
- the influence of leptin on gonadotropin secretion is demonstrated in female adolescents with anorexia nervosa during starvation and re-feeding
|
| |
11997182 |
- Data show that pro-inflammatory cytokines dose-dependently decrease the production and release of leptin from adipose tissue fragments in vitro.
|
| |
12582219 |
- leptin secretory responses occur at physiological doses of hydrocortisone, are obliterated by fasting, and thus may be of metabolic significance
|
| |
12590942 |
- Activation of JAK1, JAK2 and STAT3 is necessary for leptin-induced transactivation of NPY gene through the leptin-response element in neural cells.
|
| |
12660878 |
- This study provides further evidence that IL-6, leptin, and adiponectin are associated with impaired fibrinolysis in overweight hypertensive humans.
|
| |
12857430 |
- significant correlation was observed between serum leptin levels and both body mass index and insulin resistance status in polycystic ovary syndrome
|
| |
11994543 |
- the differential distribution of mRNA for leptin and its receptor suggests an important autocrine and paracrine role for leptin in human endometriosis.
|
| |
12468269 |
- leptin release is exclusively a function of adipocytes while prostanoids are made by both adipocytes and the other cells present in human adipose tissue
|
| |
12213831 |
- Data show that leptin gene expression in human preadipocytes is switched on by maturation-induced demethylation of distinct CpGs in its proximal promoter.
|
| |
12037648 |
- leptin 3'-tetranucleotide repeat is associated with high body mass index(BMI) in adult Samoans with allele 226 having a low frequency in the high BMI group
|
| |
12552573 |
- potential association between endogenous circulating leptin and sympatho-vagal activities in age- and height-matched obese and nonobese healthy young women
|
| |
14506615 |
- serum C-reactive protein was positively related to serum leptin and QTc interval and negatively correlated with HDL-cholesterol in young apparently health men
|
| |
12100031 |
- These results support the hypothesis of leptin as a stimulatory cytokine and point to a possible role for leptin in the pathophysiology of human HIV infection.
|
| |
12899679 |
- Sleep influences nocturnal leptin profile. May have implications for role of sleep in metabolic regulation and aetiologies of obesity and the night eating syndrome.
|
| |
12734788 |
- The main determinants for leptin levels in type 2 diabetic subjects as in healthy subjects are associated with measures of insulin resistance and insulin secretion.
|
| |
12721156 |
- data demonstrate differential regulation of leptin secretion and pulsatility in adipocytes and synchronicity between leptin and growth hormone, cortisol, and insulin
|
| |
12376297 |
- Serum leptin levels are significantly higher in menopausal women than in women with regular menstrual cycle, and can be down-regulated by hormone replacement therapy.
|
| |
11997181 |
- Results indicate that leptin, after binding its receptor, leads to activation of Grb2 and several pathways for signal transduction that might lead to mitogenic effects.
|
| |
12734209 |
- activating transcription factor 1(AP-1) motif is important in determining the up-regulatory effects induced by leptin on aromatase expression in MCF-7 breast cancer cells
|
| |
12955866 |
- Over the 8-month intervention period, regardless of group membership, youths who had the lowest increase in cardiovascular fitness tended to have the highest increase in leptin.
|
| |
12779248 |
- Results suggest that leptin might elicit angiogenesis through vascular endothelial growth factor induction as well as pigment epithelium-derived factor suppression in pericytes.
|
| |
12484512 |
- Statistically significant positive correlation was between changes in blood pressure and changes in leptin levels. Leptin may play role in pathophysiology of obese hypertension.
|
| |
12218380 |
- analysis of peroxisome proliferator-activated receptor-gamma2 genotype showed that leptin levels were determined by the Pro12Ala mutation in type-2 diabetic women but not in men
|
| |
12218376 |
- nocturnal leptin secretion in children with myelomeningocele was significantly different from secretion in children with growth hormone deficiency and normal variant short stature
|
| |
12702488 |
- Placental leptin expression was examined in representative species of the two most abundant mammalian orders, Rodentia and Chiroptera, and in cultured human choriocarcinoma (BeWo) cells
|
| |
12354677 |
- PTP1B reduces the level of gene expression of SOCS3 and other leptin-regulated genes, and conversely, the expression of genes down-regulated by leptin was enhanced by PTP1B over-expression
|
| |
12690081 |
- synthesis of adipose tissue tumor necrosis factor alpha and leptin could induce the production acute-phase reactants, thus contributing to the maintenance of chronic low-grade inflammation
|
| |
12634431 |
- data suggest that both adiponectin and leptin are associated with central body fat distribution, and serum adiponectin concentrations are determined predominantly by the visceral fat compartment
|
| |
12690082 |
- plasma leptin levels, rather than nonesterified fatty acids and tumor necrosis factor receptor 1, may play a significant role in the development of hyperinsulinemia and insulin resistance in children
|
| |
12211425 |
- the sex-dependent specificity of the relationship between leptin and bone mineral density (BMD) in human studies could be caused by serum leptin levels that are two- to threefold higher in women than in men
|
| |
12031914 |
- Leptin increased acute myelogenous leukemia blast release of IL-1beta, IL6, tumor necrosis factor alpha and granulocyte-macrophage colony-stimulating factor, and increased spontaneous AML blast proliferation
|
| |
12529499 |
- graded positive relationship between plasma leptin levels and blood pressure was observed in sample of untreated male adults; association was independent of age, BMI, abdominal adiposity, and fasting plasma insulin
|
| |
9205417 |
- Leptin is generally thought to play a key role in the regulation of eating. the role of leptin in the regulation of eating in obese binge- and non-binge-eating women during exposure to food and food-related stimuli.
|
| |
12679437 |
- data suggest that plasma leptin is reduced in untreated type 2 diabetes probably as a consequence of reduced insulin secretion and that circulating leptin concentrations are differentially affected by monodrug therapy
|
| |
11935372 |
- Results support the involvement of NGF, BDNF, leptin, and mast cells in human coronary atherosclerosis and metabolic syndrome, implying neuroimmune and adipoimmune pathways in the pathobiology of these cardiovascular disorders.
|
| |
12679442 |
- conclude that weight loss early in the course of dietary fat restriction occurs independently of increased plasma leptin levels, but that a later increase in amplitude of the 24-h leptin signal may contribute to ongoing weight loss
|
| |
12364439 |
- high levels of soluble leptin receptor in emaciation may reflect an up-regulation to suppress leptin action during energy deficiency and with free leptin index is a tool to investigate the leptin axis during growth and sexual maturation
|
| |
11800057 |
- evaluation of the relative contributions of existing obesity and a family history of obesity (FHOB) to blood pressure (BP) level, sympathetic activity, plasma leptin and insulin levels in young men without a family history of hypertension.
|
| |
12626032 |
- increased tumor necrosis factor-alpha and leptin levels may contribute to insulin resistance in gestational diabetes mellitus and in the third trimester of normal pregnancy and may negatively influence the anthropometric parameters of the newborns
|
| |
12647279 |
- in morbid obesity, there appears to be an association between serum concentrations of leptin and a more favorable lipid profile, whereas there is no direct interrelation between serum concentrations of cholesterol and dehydroepiandrosterone sulfate
|
| |
12727933 |
- role in regulating neuroendocrine and metabolic function during an acute fast; role of leptin in normalizing several starvation-induced neuroendocrine changes may have implications for the pathophysiology and treatment of eating disorders and obesity
|
| |
12149424 |
- anti-CD3-driven proliferation of memory T cells was inhibited by leptin, whereas that of naive T cells was markedly enhanced; despite the inhibition of proliferation of the memory T cells, their production of interferon-gamma was substantially increased
|
| |
12843185 |
- leptin in the circulation may increase more rapidly during development than indicated by total leptin levels, and that these changes may serve as one of the signals to the central nervous system that metabolic conditions are adequate to support puberty.
|
| |
11890967 |
- in obese women serum leptin level and the occurrence of binge eating are unrelated; relationship between serum leptin level and restraint of food intake observed in eating disordered patients and in overweight preadolescent girls is shared by obese women
|
Term