SymCurv:
1. calculates the curvature of a sequence
2. imposes symmetry constraints on curvature
3. scores the symmetry of the curvature data
4. uses a greedy algorithm to parse the sequence in nucleosome-bound and nucleosome-free segments

The input is a DNA sequence in FASTA format. The output is a set of predictions of nucleosome positions in GFF format. Each prediction carries a nucleosome-potential score.

SymCurv uses two alternative sets of parameters to calculate the DNA curvature and thus provides as output two alternative nucleosome profiles. The profile obtained with (nuc) parameters refers to a "stationary" condition, while the one obtained with (DNase) parameters refers to a "dynamic" state. Different positions in the two profiles represent nucleosomes whose positioning is more prone to undergo changes under certain conditions.